Author: Michelle Holland

Ascites Calprotectin

Spontaneous bacterial peritonitis (SBP) is an acute bacterial infection of ascitic fluid. It primarily occurs in patients with advanced cirrhosis and, generally, no source of the infecting agent is easily identifiable.

Fever, abdominal pain, altered mental status, abdominal tenderness, or hypotension in cirrhosis cases indicates SBP. In addition, patients with ascites admitted to the hospital for other reasons should undergo paracentesis to look for evidence of SBP.

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Does NSAID use affect the Faecal Calprotectin Result?

In a word – yes!

Is this clinically significant? in another word, no!

Most non-steroidal anti-inflammatory drugs (NSAID) cause gastric damage in short-term volunteer studies, ranging from erythema to ulcers. Recent estimates suggest that gastrointestinal (GI) bleeding attributable to nonselective NSAID accounts for nearly 34% of all GI bleeding cases (mostly upper GI bleeding) in the US and may have resulted in over 32,000 hospitalisations per year during the last decade.

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Sharing Best Practice

The recent Calprotectin Regional User Group meetings, organised by Alpha Laboratories, generated lively and informative discussions between new, experienced and some potential calprotectin assay users. Over 40 participants attended across the three meetings held in London, Birmingham and Manchester, travelling from as far afield as Truro and Glasgow. The majority of attendees had already set

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