Calprotectin in Serum

Calprotectin in Serum

Calprotectin is a soluble protein that is found in white cells; it is part of the bodies defence mechanism and has strong antibacterial and antifungal properties through its ability to sequester metal ions (calcium, zinc, magnesium).

There is a much calprotectin in white cells as there is haemoglobin in red cells accounting for around 60% of the soluble protein content. In conditions which provoke an inflammatory response the level of calprotectin in the blood can increase significantly and although it is a non-specific marker, it can be used to diagnose and determine the severity of certain conditions in conjunction with the other clinical evidence. The diagnostic advantage of calprotectin detection over other disease markers is that it is stored in the cell and released immediately in response to local inflammation. In contrast, other markers may be generated by downstream pathways or need to be synthesised de novo leading to delays or other factors influencing response.

Examples of conditions where serum calprotectin levels could be useful are:

  • Rheumatoid and Juvenile idiopathic arthritis
  • Early marker for Sepsis
  • Early marker for acute coronary syndromes
  • Cystic fibrosis

Quantum Blue® Calprotectin in Serum

The Quantum blue test system combines the ease and speed of lateral flow technology (a bit like a pregnancy test device) with full quantitation by means of a small bench top reading device (about the size of a desk top telephone order code: BI-POCTR-ABS).

The system can be used in the laboratory if the volume of tests isn’t too high, or it can be used in clinics as a point of care option. There are 25 tests in each kit and all are individually sealed so you can use them one at a time if required and results are available in 12 minutes.

  • Assay range: 0.42 – 10µg/ml
  • Assay time: 12 minutes
  • Sample type: Serum
  • Sample volume required: 20µl

Click here to read the Publications relating to Calprotectin Serum

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Serum Calprotectin Quantitative Lateral-flow Test
Product Code Description Pack Size
LF-MRP25 Quantum Blue® sCAL 25 Tests

sCAL ELISA – Calprotectin in Serum

The sCAL ELISA is a micro-titre based assay kit for determination of calprotectin in serum samples. All reagents, standards and controls are provided in one kit and are ready for use. There is no requirement for reconstituting any component, apart from the wash buffer so this minimises any errors and ensures a long shelf life. The ELISA can be performed manually or on a DS2 automated processor to reduce hands–on time in higher throughput environments.

  • Assay range: 0.42 – 24µg/ml
  • Assay time: 75 minutes
  • Sample type: Serum

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Serum Calprotectin Quantitative Lateral-flow Test
Product Code Description Pack Size
EK-MRP8/14 Serum Calprotectin ELISA 96 well plate
Serum-Calprotectin-User-Report

Helping to Manage Juvenile Idiopathic Arthritis

Great Ormond Street Hospital User Report – Serum Calprotectin Monitoring

Click here to read the Publications relating to Calprotectin Serum

Key Literature

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