fCAL® turbo

fCAL turbo-Publications
Evaluation of the BÜHLMANN fCAL® turbo assay on the Abbott Architect C8000

The CALEX® cap extraction devices and fCAL turbo®  method on the Abbott Architect C8000 analyser, demonstrate good comparability with other established methods, with no significant interference with other chemistries and have led to improved workflow for faecal calprotectin analysis

Khir M. et al. Poster at IBMS Congress 2019

The fecal marker calprotectin derived from neutrophilic granulocytes is increasingly used in the diagnosis and monitoring of patients suffering from chronic inflammatory bowel diseases. The increasing amount of this analysis is a challenge in the routine laboratory and urgently ask for enhanced automation.

Verification and implementation of faecal calprotectin using the BÜHLMANN fCAL® turbo assay

Here we demonstrate the BÜHLMANN fCAL® turbo assay on the Abbott ARCHITECT platform is fit for purpose and we have recently received UKAS accreditation for this assay. Close collaboration with our  Gastroenterology team has enabled us to provide a new IBS local pathway for primary care to follow.

Evans et al. (2017) ACB Focus
The way to total automation of calprotectin measurement in faeces with Bühlmann fCAL® turbo

The preparation of stool specimens for Calprotectin determination with CALEX® and the analysis with the new fCAL turbo on the Cobas® c501 module (Roche Diagnostics) is practically a fully automated testing procedure.

Schallberger et al. (2016) Swiss MedLab
Evaluation of the BÜHLMANN fCAL Turbo Calprotectin Method on the Roche Cobas 6000 (c501)

The BÜHLMANN fCAL™ turbo method demonstrates acceptable performance. The positive bias at higher concentrations is accounted for in local guidelines. A commutable reference material for calprotectin is required to define analytical accuracy in the future.

Bowe et al. North Cumbria University Hospitals
BÜHLMANN fCAL® turbo Faecal Calprotectin Assay on Abbott Architect C8000

The fCAL turbo is very adaptable and suited for rapid analysis on the Abbott Architect C8000 Clinical Chemistry Analyser with no interference to any of the other chemistries.

M. O’Connell, Mercy University Hospital
Analytical Performance of a Fecal CALPROTECIN (fCAL) PETIA Test

The new latex turbidimetric procedure for determining calprotectin is an attractive alternative to ELISA allowing random access and full automation of fecal calprotectin quantitation. Moreover, it represents an accurate and precise method to determine calprotectin levels in fecal extracts in a measuring range from 15 to 10’000 µg/g.

Sunde et al. 2015 EuroMedLab
Analytical and diagnostic performance of two automated fecal calprotectin immunoassays for detection of inflammatory bowel disease

The newly developed stool extraction device protocols showed acceptable and comparable performance to the stool weight method. Overall, the automated Liaison® Calprotectin and fCAL™ turbo assay showed good analytical and diagnostic performance for detection of IBD.

De Sloovere et al. (2016) Clin Chem Lab Med
Evaluation of the BÜHLMANN fCAL Turbo Faecal Calprotectin Assay on the Abbott Architect C8000. Comparison to the Phadia EliA and the IBDoc® home test kit

fCAL turbo is very adaptable to the Abbott Architect C8000 analyser. The CALEX ® cap extraction devices are easy to use and practical. Inter-assay variability demonstrated, and recommends users to participate in the UK NEQAS Scheme . No interference to any of the other chemistries.

O’Connell (2017) Research Project Scientific Paper